Cagrilintide

What it is: A long-acting amylin analog that slows gastric emptying and reduces food intake — works through a different pathway than GLP-1s.

What it does: Expect appetite suppression, fullness after smaller meals, and stronger weight loss when stacked with semaglutide. Hits hunger from a different angle than GLP-1s alone.

How it's used: Once-weekly subcutaneous injection.